![]() But! Your muscle mitochondria, which is where you really want the iron, are showing otherwise. Trying to overwhelm hepcidin with iron from soluble salts artificially inflates iron storage protein levels (ferritin and others) without giving your muscles the iron they need (myoglobin), effectively tricking blood tests into showing that you are replete with iron. That only compounds the very reason for taking iron, and it necessitates large doses of iron from soluble salts to overwhelm the hepcidin, which is only released in response to those large doses, for any hope of a desired effect. Hepcidin even explains why the usual iron treatments with soluble iron salts like ferrous sulfate need exorbitant doses and have side effects – those salts easily let iron loose, flooding your system and triggering hepcidin release. The harder you work, the less your body can utilize iron, but the more your body needs it – again, the Iron Enigma. Hepcidin’s role is to prevent oxidative toxicity from spreading further via loose iron however, since intense exercise, overexertion and running out of carbs for muscular energy production normally cause iron-induced inflammation resulting in cell and tissue nano/microdamage, hepcidin explains why iron is still a specific problem for endurance exercisers. It does so by removing ferroportin (iron transport protein) from membranes of key tissues, DECREASING the amount of iron absorbed by your gut, that gets recycled by immune system macrophages (garbage collectors and recyclers) and that is sent into circulation from gut, liver and red blood cells. When released, hepcidin works fast to choke off the biggest channels of iron supply, transport, and movement. In particular, it has been a revelation for tying together the Iron Enigma with energy metabolism problems, including carb/fat controversies. Though it’s still too “new” for textbook understanding, hepcidin has a small but growing number of studies and comprehension. One of the quietest BIG STORIES in human nutrition has been the realization that iron metabolism is actually psychotically controlled by a recently identified protein “hormone” named hepcidin. Obviously EFS and EFS-PRO address the former, and the new MultiV addresses the latter better than any formula we – or anyone else – has produced before. ensure a consistent, steady, non-exorbitant intake of iron from a true chelate – Ferrochel ®.provide hydration/carb/electrolyte supply during exercise to reduce or delay iron-caused inflammation and.The solution to the Iron Enigma is two-fold: Compensatory inflammation sends an alert: Damage! Send Help! Part of the help message triggers the rapid release of a protein called hepcidin, a master regulator of iron metabolism that ironically impedes your body’s ability to get the iron that it needs when it needs it most. But even tiny amounts of iron loosened from its enzymes, storage and transport proteins can start chain reactions that make thousands of hydroxyl radicals and thousands of damaged cellular proteins and structural components. Laws of Nature mandate that iron atoms are always stuck on a protein and not solubilized, or else, problems ensue. This is all because iron is like a biological, double-edged sword. Massive iron supplementation/therapy can restore iron and performance levels, but inflammation from excess iron due to these options is an unresolved, haunting issue – the root of the Iron Enigma. LEA/RED-S is associated with low iron stores, low hemoglobin (red blood cells), and even anemia (low blood cells) – even with “adequate” iron intakes. Recent research has characterized the prevalence of LEA (Low Energy Availability) in women and RED-S (Relative Energy Deficiency in Sport) when you train very hard and/or do not consume enough energy/calories (carbs). You would think that dietary advice, simply taking a multiple vitamin-mineral (MVM) with iron, or popping an extra stand-alone iron supplement would fix that issue, but no! The iron problem persists. Iron is also widely regarded as the #1 problem with micronutrients and exercise.Īmong women and men who exercise, iron still shows a 15-50% and 5-30% deficiency rate, respectively. Iron is super-essential for generating energy from oxygen and all those carbs you eat, making it critical for endurance athletes. With all those nutrients flying around, which ones are the most important? The sexiest? The major drivers for exercise performance and recovery? Here, we break them down and hit you with the highlights. ![]() MultiV is comprehensive – 26 essential vitamins & minerals and four important extracts of 32 foodstuffs. ![]() MultiV – our “basic” MVM (Multiple Vitamin-Mineral with additional nutrients) has been updated, rebalanced and made over to be even more powerful than before, with significant changes based on the latest nutrition science and experiential feedback.
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